[Shorter Sleep] may Increase Genetic Risks for Obesity

ScienceDaily (June 17, 2011) — Sleeping less at night may increase the expression of genetic risks for obesity, while getting plenty of sleep may suppress genetic influences on body weight, suggests an abstract being presented in Minneapolis, Minn., at SLEEP 2011, the 25th Anniversary Meeting of the Associated Professional Sleep Societies LLC (APSS).

Results of a study of 1,811 pairs of twins show that the heritability of sleep duration was 32 percent, and shared environmental influences on sleep duration were negligible. Longer sleep duration was associated with decreased body mass index, which is a measure of body fat based on height and weight.
Behavioral genetic modeling found significant interactions between self-reported, habitual sleep duration and both genetic and shared environmental influences on BMI. The heritability of BMI when sleep duration equaled seven hours was more than twice as large as the heritability of BMI when sleep duration equaled nine hours.
“The heritability of body weight decreased as sleep duration increased,” said principal investigator Dr. Nathaniel Watson, associate professor of neurology at the University of Washington and co-director of the UW Medicine Sleep Center. “There appears to be something about short sleep that creates a permissive environment for expression of obesity-related genes.”
The study involved a population-based sample of 1,811 pairs of identical and fraternal twins from the University of Washington Twin Registry. They had a mean age of about 37 years. Height, weight and habitual sleep duration were collected by self-report surveys. Participants were slightly overweight with a mean BMI of 25.4, and they had a mean sleep duration of about seven hours and 11 minutes per night. Data were analyzed using behavioral genetic interaction models.
According to Watson, the study is an important addition to the existing body of research on the relationship between sleep duration and BMI.
“Epidemiological and experimental studies have shown short sleep is associated with obesity,” said Watson. “Our work takes this a step further, showing that short sleep facilitates expression of obesity-related genes.”
The authors concluded that future research aiming to identify specific genotypes for BMI may benefit from considering the moderating role of sleep duration.
In a smaller study of 612 twin pairs published in the Journal of Clinical Sleep Medicine in 2010, Watson found that short sleep was associated with elevated BMI following careful adjustment for genetics and shared environment. In a study published in JAMA in 2010, the CDC estimated that 68 percent of U.S. adults were overweight or obese in 2007 — 2008

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Obesity and Alcohol cause liver problems

Do you really believe obesity could cause the liver problem? It is well known that alcohol consumption is the main reason for the highly risked liver problems but the recent study results are really surprising many as even the obesity would cause such problems on liver.

The term “Cirrhosis of the liver” is the rapidly increasing health problem in both men and women in the UK and even in the rest of the world. The recent study has noted that this disease is dangerous as it would even cause death. Alcohol is the main cause of this deadly disease and even Body Mass Index (BMI) is the other factor which would cause cirrhosis.

The relative increase in BMI on women is highly related to the increase in risk of cirrhosis. It is estimated that increase of 28% risk for cirrhosis for every 5 unit increase in the individuals BMI. The study also indicates that the rate of causing cirrhosis by alcohol is 42% where as obesity and increase BMI attributes around 17% of fatal liver cases.

So in order to protect your liver, it is necessary to maintain the proper BMI. Excess amount of alcohol gives you many health problems and consumption of alcohol should be limited in order to get longer life.

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